The liver and pancreas are closely related organs and their functions complement each other. Cutaneous manifestations are not necessarily linked to diseases affecting these organs. The location of these organs: the liver is close to the stomach on the rather high right side; the pancreas is located below the stomach. The cases to identify that there is a disease affecting these organs: The skin turns yellow or has red spots, itching all over the body, bad breath, constipation or diarrhea, Fatigue, feeling of heaviness on the right side if the liver is diseased and on the left side if there is a problem with the pancreas.